Pharmacogenomics and Personalized Medicine
(Methods in Pharmacology and Toxicology)
With all the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities and obstacles in its application. Focusing on DNA data and associated analytical methodologies, with a consideration for complementary RNA-based studies, this volume includes a wide array of vital, cutting-edge research.
Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of the current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.
Infant Gender Selection & Personalized Medicine: Consumer's Guide
Personalized medicine is what this book is about—tailoring your lifestyle, food, medicines, treatments, and reproductive choices to your genetic signature. According to Dr. Andrew Y. Silverman, MD, PhD, "The desire to influence the sex of the next child is probably as old as recorded history."
"Gender selection is possible because of the way in which sex is determined by our chromosomes. Dr. Ericsson devised patented methods by which X and Y sperm can be separated through filtering processes. Sperm are 'layered' over a column of human serum albumin, and they swim down the gradient where they are collected in the bottom layer."
Textbook of Personalized Medicine
Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic.
There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.
Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine
The new "molecular economy," fundamentally driven by understanding molecules and their interactions, has spawned an exciting discipline referred to as "clinical" pharmacogenomics or pharmacogenetics. Combining this discipline with our knowledge of protein function and regulation (proteomics), a more complete understanding of systems physiology is achieved-giving rise to a "systems biology" perspective. From this new perspective, the practice of medicine is becoming more dependent on the application of biomarkers-genomics, proteomics, and other functional biomarkers-toward personalized medicine, thus allowing a practical convergence to optimize matching of the right patient and the right diagnosis with the right drug and the right dose at the right time. To enable the practice of personalized medicine with an understanding of pharmacogenomics and proteomics, this book reviews:
- the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis;
- methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics;
- specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and
- selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
As the new molecular economy emerges, this text provides the basic pharmacogenomic and proteomic tools needed to understand this new, rapidly evolving, and exciting discipline.
Genomic Medicine: Articles from the New England Journal of Medicine
"Fifteen years ago, many questioned the wisdom of sequencing the human genome. There were concerns not only about the technical feasibility of such an effort, but also that its scientific worth would prove too modest to warrant the investment of human and financial capital that the project would require. This collection of essays stands as eloquent testimony to those who overcame such doubts to create, nurture, and finish the sequencing of the human genome in April 2003, a date that will forever stand out in human history. The wide and public availability of the human genome sequence and the other tools spawned by the Human Genome Project have helped to create an unparalleled era of biomedical discovery. It has opened up new avenues for the understanding of the biology of human health and disease. Many of these avenues remain to be fully explored, but this volume already demonstrates that information about genetics and genomics is increasingly permeating our clinical approach to patients."—from the Foreword by Dr. Elias Zerhouni
For more than a century, knowledge about the role of genes has been gradually reshaping perceptions of our health and of ourselves. From Mendel's work with plants and Watson and Crick's model of DNA's double-helix structure to the recent decoding of the human genome, the tremendous advances in our ability to analyze and interpret gene sequences are revolutionizing many aspects of medicine. Genomic Medicine collects and updates an acclaimed series of articles published in the pages of the New England Journal of Medicine since November 2002 that together provide an authoritative and comprehensive overview of the latest developments in the field of medical genetics and an exploration of where these advances might take medicine over the next decade.
Beginning with a fundamental primer and a useful glossary of terms, the book offers the latest information on the use of genetics to screen, diagnose, and treat a wide variety of diseases, including breast and ovarian cancer and cardiovascular, Alzheimer, and Parkinson disease. Also included are discussions of population screening, pharmacogenetics, and the ethical, legal, and social dimensions of genomic medicine. Edited by leaders in the field, written by experts from around the globe, and brimming with full-color illustrations, Genomic Medicine is an indispensable guide to the full potential of the DNA-based transformation of medicine.
The Genome Book: A Must-Have Guide to Your DNA for Maximum Health
If you re not a scientist or genetics professional, the whole concept of genomic medicine may sound a lot like science fiction. In The Genome Book: A Must-Have Guide to Your DNA for Maximum Health, author April Lynch brings you a thorough but easy-to-understand explanation of the growing medical benefits provided by the decoding of the human genome. She discusses DNA' s role in nutrition, cancer, blood and heart conditions, and even behavior, and gives an overview of genetic testing and genomic care. She also discusses how your DNA is passed on to your children, and the testing procedures that are now available when starting a family.
You will also learn how to compile a family medical history to help pinpoint potential health risks and start making lifestyle and nutrition decisions tailored to your genes. There s even a chapter on laws regarding privacy and health insurance including the new federal Genetic Information Nondiscrimination Act as well as sections on ethical considerations and questionable commercial tests. The book includes a collection of real-life cases in which people s lives have been reshaped by their genomic choices, presented by genetic counselor Vickie Venne, a past president of the National Society of Genetic Counselors.
The Language of Life: DNA and the Revolution in Personalized Medicine
"The future of customized medicine is in your DNA; don't wait until you are sick to learn why." (Dr. Mehmet Oz, author of You: The Owner's Manual )
"With fluid prose and compelling narratives, Francis Collins makes modern medical science vivid and accessible. This book sets out hope without hype, and will enrich the mind and uplift the heart." (Jerome Groopman, M.D., Recanati Professor, Harvard Medical School, Author of How Doctors Think )
"His groundbreaking work has changed the very ways we consider our health and examine disease." (President Barak Obama )
"Man's knowledge of man is undergoing the greatest revolution since Leonardo, and Francis Collins is at the leading edge of it. I am a better doctor today because Dr. Collins was my genetics professor in medical school, and now, the world gets to benefit from his wisdom by reading The Language of Life." (Dr. Sanjay Gupta, Neurosurgeon at Emory University and Chief Medical Correspondent for CNN )